ChloroquineV1, an2020, Analysis, bibRecord, 000208

Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors

Identifieur interne : 000208 ( an2020/Analysis ); précédent : 000207; suivant : 000209

Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors

Auteurs : Joe R. Delaney [États-Unis] ; Chandni B. Patel [États-Unis] ; Jaidev Bapat [États-Unis] ; Christian M. Jones [États-Unis] ; Maria Ramos-Zapatero [États-Unis] ; Katherine K. Ortell [États-Unis] ; Ralph Tanios [États-Unis] ; Mina Haghighiabyaneh [États-Unis] ; Joshua Axelrod [États-Unis] ; John W. Destefano [États-Unis] ; Isabelle Tancioni [États-Unis] ; David D. Schlaepfer [États-Unis] ; Olivier Harismendy [États-Unis] ; Albert R. La Spada [États-Unis] ; Dwayne G. Stupack [États-Unis]

Source :

PLoS Genetics [ 1553-7390 ] ; 2020.

RBID : PMC:6953790

Abstract

Autophagy, particularly with BECN1, has paradoxically been highlighted as tumor promoting in Ras-driven cancers, but potentially tumor suppressing in breast and ovarian cancers. However, studying the specific role of BECN1 at the genetic level is complicated due to its genomic proximity to BRCA1 on both human (chromosome 17) and murine (chromosome 11) genomes. In human breast and ovarian cancers, the monoallelic deletion of these genes is often co-occurring. To investigate the potential tumor suppressor roles of two of the most commonly deleted autophagy genes in ovarian cancer, BECN1 and MAP1LC3B were knocked-down in atypical (BECN1+/+ and MAP1LC3B+/+) ovarian cancer cells. Ultra-performance liquid chromatography mass-spectrometry metabolomics revealed reduced levels of acetyl-CoA which corresponded with elevated levels of glycerophospholipids and sphingolipids. Migration rates of ovarian cancer cells were increased upon autophagy gene knockdown. Genomic instability was increased, resulting in copy-number alteration patterns which mimicked high grade serous ovarian cancer. We further investigated the causal role of Becn1 haploinsufficiency for oncogenesis in a MISIIR SV40 large T antigen driven spontaneous ovarian cancer mouse model. Tumors were evident earlier among the Becn1+/- mice, and this correlated with an increase in copy-number alterations per chromosome in the Becn1+/- tumors. The results support monoallelic loss of BECN1 as permissive for tumor initiation and potentiating for genomic instability in ovarian cancer.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953790

DOI: 10.1371/journal.pgen.1008558
PubMed: 31923184
PubMed Central: 6953790

Affiliations:

Links to Exploration step

PMC:6953790

Le document en format XML

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<author><name sortKey="Haghighiabyaneh, Mina" sort="Haghighiabyaneh, Mina" uniqKey="Haghighiabyaneh M" first="Mina" last="Haghighiabyaneh">Mina Haghighiabyaneh</name>
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<author><name sortKey="Harismendy, Olivier" sort="Harismendy, Olivier" uniqKey="Harismendy O" first="Olivier" last="Harismendy">Olivier Harismendy</name>
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<placeName><region type="state">Californie</region>
</placeName>
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<affiliation wicri:level="2"><nlm:aff id="aff002"><addr-line>Department of Obstetrics, Gynecology, and Reproductive Sciences, UC San Diego School of Medicine, La Jolla, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Obstetrics, Gynecology, and Reproductive Sciences, UC San Diego School of Medicine, La Jolla, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bapat, Jaidev" sort="Bapat, Jaidev" uniqKey="Bapat J" first="Jaidev" last="Bapat">Jaidev Bapat</name>
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</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>UC San Diego Moores Cancer Center, La Jolla, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff002"><addr-line>Department of Obstetrics, Gynecology, and Reproductive Sciences, UC San Diego School of Medicine, La Jolla, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Obstetrics, Gynecology, and Reproductive Sciences, UC San Diego School of Medicine, La Jolla, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff005"><addr-line>Department of Pediatrics and Division of Biological Sciences, UC San Diego School of Medicine, La Jolla, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics and Division of Biological Sciences, UC San Diego School of Medicine, La Jolla, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jones, Christian M" sort="Jones, Christian M" uniqKey="Jones C" first="Christian M." last="Jones">Christian M. Jones</name>
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</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina</wicri:regionArea>
<placeName><region type="state">Caroline du Sud</region>
<settlement type="city">Columbia (Caroline du Sud)</settlement>
</placeName>
<orgName type="university">Université de Caroline du Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Ramos Zapatero, Maria" sort="Ramos Zapatero, Maria" uniqKey="Ramos Zapatero M" first="Maria" last="Ramos-Zapatero">Maria Ramos-Zapatero</name>
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</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>UC San Diego Moores Cancer Center, La Jolla, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
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</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Obstetrics, Gynecology, and Reproductive Sciences, UC San Diego School of Medicine, La Jolla, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff005"><addr-line>Department of Pediatrics and Division of Biological Sciences, UC San Diego School of Medicine, La Jolla, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics and Division of Biological Sciences, UC San Diego School of Medicine, La Jolla, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ortell, Katherine K" sort="Ortell, Katherine K" uniqKey="Ortell K" first="Katherine K." last="Ortell">Katherine K. Ortell</name>
<affiliation wicri:level="4"><nlm:aff id="aff004"><addr-line>Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina</wicri:regionArea>
<placeName><region type="state">Caroline du Sud</region>
<settlement type="city">Columbia (Caroline du Sud)</settlement>
</placeName>
<orgName type="university">Université de Caroline du Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Tanios, Ralph" sort="Tanios, Ralph" uniqKey="Tanios R" first="Ralph" last="Tanios">Ralph Tanios</name>
<affiliation wicri:level="4"><nlm:aff id="aff004"><addr-line>Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina</wicri:regionArea>
<placeName><region type="state">Caroline du Sud</region>
<settlement type="city">Columbia (Caroline du Sud)</settlement>
</placeName>
<orgName type="university">Université de Caroline du Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Haghighiabyaneh, Mina" sort="Haghighiabyaneh, Mina" uniqKey="Haghighiabyaneh M" first="Mina" last="Haghighiabyaneh">Mina Haghighiabyaneh</name>
<affiliation wicri:level="2"><nlm:aff id="aff001"><addr-line>UC San Diego Moores Cancer Center, La Jolla, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>UC San Diego Moores Cancer Center, La Jolla, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff002"><addr-line>Department of Obstetrics, Gynecology, and Reproductive Sciences, UC San Diego School of Medicine, La Jolla, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Obstetrics, Gynecology, and Reproductive Sciences, UC San Diego School of Medicine, La Jolla, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Axelrod, Joshua" sort="Axelrod, Joshua" uniqKey="Axelrod J" first="Joshua" last="Axelrod">Joshua Axelrod</name>
<affiliation wicri:level="2"><nlm:aff id="aff001"><addr-line>UC San Diego Moores Cancer Center, La Jolla, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>UC San Diego Moores Cancer Center, La Jolla, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff002"><addr-line>Department of Obstetrics, Gynecology, and Reproductive Sciences, UC San Diego School of Medicine, La Jolla, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Obstetrics, Gynecology, and Reproductive Sciences, UC San Diego School of Medicine, La Jolla, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Destefano, John W" sort="Destefano, John W" uniqKey="Destefano J" first="John W." last="Destefano">John W. Destefano</name>
<affiliation wicri:level="4"><nlm:aff id="aff004"><addr-line>Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina</wicri:regionArea>
<placeName><region type="state">Caroline du Sud</region>
<settlement type="city">Columbia (Caroline du Sud)</settlement>
</placeName>
<orgName type="university">Université de Caroline du Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Tancioni, Isabelle" sort="Tancioni, Isabelle" uniqKey="Tancioni I" first="Isabelle" last="Tancioni">Isabelle Tancioni</name>
<affiliation wicri:level="2"><nlm:aff id="aff001"><addr-line>UC San Diego Moores Cancer Center, La Jolla, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>UC San Diego Moores Cancer Center, La Jolla, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff002"><addr-line>Department of Obstetrics, Gynecology, and Reproductive Sciences, UC San Diego School of Medicine, La Jolla, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Obstetrics, Gynecology, and Reproductive Sciences, UC San Diego School of Medicine, La Jolla, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schlaepfer, David D" sort="Schlaepfer, David D" uniqKey="Schlaepfer D" first="David D." last="Schlaepfer">David D. Schlaepfer</name>
<affiliation wicri:level="2"><nlm:aff id="aff001"><addr-line>UC San Diego Moores Cancer Center, La Jolla, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>UC San Diego Moores Cancer Center, La Jolla, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff002"><addr-line>Department of Obstetrics, Gynecology, and Reproductive Sciences, UC San Diego School of Medicine, La Jolla, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Obstetrics, Gynecology, and Reproductive Sciences, UC San Diego School of Medicine, La Jolla, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Harismendy, Olivier" sort="Harismendy, Olivier" uniqKey="Harismendy O" first="Olivier" last="Harismendy">Olivier Harismendy</name>
<affiliation wicri:level="2"><nlm:aff id="aff001"><addr-line>UC San Diego Moores Cancer Center, La Jolla, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>UC San Diego Moores Cancer Center, La Jolla, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff006"><addr-line>Division of Biomedical Informatics, Department of Medicine, UC San Diego School of Medicine, La Jolla, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Biomedical Informatics, Department of Medicine, UC San Diego School of Medicine, La Jolla, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="La Spada, Albert R" sort="La Spada, Albert R" uniqKey="La Spada A" first="Albert R." last="La Spada">Albert R. La Spada</name>
<affiliation wicri:level="2"><nlm:aff id="aff003"><addr-line>Departments of Neurology, Neurobiology, and Cell Biology, and the Duke Center for Neurodegeneration & Neurotherapeutics, Duke University School of Medicine, Durham, North Carolina, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Neurology, Neurobiology, and Cell Biology, and the Duke Center for Neurodegeneration & Neurotherapeutics, Duke University School of Medicine, Durham, North Carolina</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff005"><addr-line>Department of Pediatrics and Division of Biological Sciences, UC San Diego School of Medicine, La Jolla, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics and Division of Biological Sciences, UC San Diego School of Medicine, La Jolla, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stupack, Dwayne G" sort="Stupack, Dwayne G" uniqKey="Stupack D" first="Dwayne G." last="Stupack">Dwayne G. Stupack</name>
<affiliation wicri:level="2"><nlm:aff id="aff001"><addr-line>UC San Diego Moores Cancer Center, La Jolla, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>UC San Diego Moores Cancer Center, La Jolla, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff002"><addr-line>Department of Obstetrics, Gynecology, and Reproductive Sciences, UC San Diego School of Medicine, La Jolla, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Obstetrics, Gynecology, and Reproductive Sciences, UC San Diego School of Medicine, La Jolla, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS Genetics</title>
<idno type="ISSN">1553-7390</idno>
<idno type="eISSN">1553-7404</idno>
<imprint><date when="2020">2020</date>
</imprint>
</series>
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<front><div type="abstract" xml:lang="en"><p>Autophagy, particularly with <italic>BECN1</italic>
, has paradoxically been highlighted as tumor promoting in Ras-driven cancers, but potentially tumor suppressing in breast and ovarian cancers. However, studying the specific role of <italic>BECN1</italic>
 at the genetic level is complicated due to its genomic proximity to <italic>BRCA1</italic>
 on both human (chromosome 17) and murine (chromosome 11) genomes. In human breast and ovarian cancers, the monoallelic deletion of these genes is often co-occurring. To investigate the potential tumor suppressor roles of two of the most commonly deleted autophagy genes in ovarian cancer, <italic>BECN1</italic>
 and <italic>MAP1LC3B</italic>
 were knocked-down in atypical (<italic>BECN1</italic>
+/+ and <italic>MAP1LC3B</italic>
+/+) ovarian cancer cells. Ultra-performance liquid chromatography mass-spectrometry metabolomics revealed reduced levels of acetyl-CoA which corresponded with elevated levels of glycerophospholipids and sphingolipids. Migration rates of ovarian cancer cells were increased upon autophagy gene knockdown. Genomic instability was increased, resulting in copy-number alteration patterns which mimicked high grade serous ovarian cancer. We further investigated the causal role of <italic>Becn1</italic>
 haploinsufficiency for oncogenesis in a MISIIR SV40 large T antigen driven spontaneous ovarian cancer mouse model. Tumors were evident earlier among the <italic>Becn1</italic>
+/- mice, and this correlated with an increase in copy-number alterations per chromosome in the <italic>Becn1</italic>
+/- tumors. The results support monoallelic loss of <italic>BECN1</italic>
 as permissive for tumor initiation and potentiating for genomic instability in ovarian cancer.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Levine, B" uniqKey="Levine B">B Levine</name>
</author>
<author><name sortKey="Kroemer, G" uniqKey="Kroemer G">G Kroemer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Guo, Jy" uniqKey="Guo J">JY Guo</name>
</author>
<author><name sortKey="Chen, Hy" uniqKey="Chen H">HY Chen</name>
</author>
<author><name sortKey="Mathew, R" uniqKey="Mathew R">R Mathew</name>
</author>
<author><name sortKey="Fan, J" uniqKey="Fan J">J Fan</name>
</author>
<author><name sortKey="Strohecker, Am" uniqKey="Strohecker A">AM Strohecker</name>
</author>
<author><name sortKey="Karsli Uzunbas, G" uniqKey="Karsli Uzunbas G">G Karsli-Uzunbas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Karsli Uzunbas, G" uniqKey="Karsli Uzunbas G">G Karsli-Uzunbas</name>
</author>
<author><name sortKey="Guo, Jy" uniqKey="Guo J">JY Guo</name>
</author>
<author><name sortKey="Price, S" uniqKey="Price S">S Price</name>
</author>
<author><name sortKey="Teng, X" uniqKey="Teng X">X Teng</name>
</author>
<author><name sortKey="Laddha, Sv" uniqKey="Laddha S">SV Laddha</name>
</author>
<author><name sortKey="Khor, S" uniqKey="Khor S">S Khor</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Strohecker, Am" uniqKey="Strohecker A">AM Strohecker</name>
</author>
<author><name sortKey="Guo, Jy" uniqKey="Guo J">JY Guo</name>
</author>
<author><name sortKey="Karsli Uzunbas, G" uniqKey="Karsli Uzunbas G">G Karsli-Uzunbas</name>
</author>
<author><name sortKey="Price, Sm" uniqKey="Price S">SM Price</name>
</author>
<author><name sortKey="Chen, Gj" uniqKey="Chen G">GJ Chen</name>
</author>
<author><name sortKey="Mathew, R" uniqKey="Mathew R">R Mathew</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Guo, Jy" uniqKey="Guo J">JY Guo</name>
</author>
<author><name sortKey="Teng, X" uniqKey="Teng X">X Teng</name>
</author>
<author><name sortKey="Laddha, Sv" uniqKey="Laddha S">SV Laddha</name>
</author>
<author><name sortKey="Ma, S" uniqKey="Ma S">S Ma</name>
</author>
<author><name sortKey="Van Nostrand, Sc" uniqKey="Van Nostrand S">SC Van Nostrand</name>
</author>
<author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, Ey" uniqKey="Liu E">EY Liu</name>
</author>
<author><name sortKey="Xu, N" uniqKey="Xu N">N Xu</name>
</author>
<author><name sortKey="O Prey, J" uniqKey="O Prey J">J O'Prey</name>
</author>
<author><name sortKey="Lao, Ly" uniqKey="Lao L">LY Lao</name>
</author>
<author><name sortKey="Joshi, S" uniqKey="Joshi S">S Joshi</name>
</author>
<author><name sortKey="Long, Js" uniqKey="Long J">JS Long</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Qiang, L" uniqKey="Qiang L">L Qiang</name>
</author>
<author><name sortKey="Zhao, B" uniqKey="Zhao B">B Zhao</name>
</author>
<author><name sortKey="Shah, P" uniqKey="Shah P">P Shah</name>
</author>
<author><name sortKey="Sample, A" uniqKey="Sample A">A Sample</name>
</author>
<author><name sortKey="Yang, S" uniqKey="Yang S">S Yang</name>
</author>
<author><name sortKey="He, Yy" uniqKey="He Y">YY He</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hewitt, G" uniqKey="Hewitt G">G Hewitt</name>
</author>
<author><name sortKey="Carroll, B" uniqKey="Carroll B">B Carroll</name>
</author>
<author><name sortKey="Sarallah, R" uniqKey="Sarallah R">R Sarallah</name>
</author>
<author><name sortKey="Correia Melo, C" uniqKey="Correia Melo C">C Correia-Melo</name>
</author>
<author><name sortKey="Ogrodnik, M" uniqKey="Ogrodnik M">M Ogrodnik</name>
</author>
<author><name sortKey="Nelson, G" uniqKey="Nelson G">G Nelson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Klionsky, Dj" uniqKey="Klionsky D">DJ Klionsky</name>
</author>
<author><name sortKey="Abdelmohsen, K" uniqKey="Abdelmohsen K">K Abdelmohsen</name>
</author>
<author><name sortKey="Abe, A" uniqKey="Abe A">A Abe</name>
</author>
<author><name sortKey="Abedin, Mj" uniqKey="Abedin M">MJ Abedin</name>
</author>
<author><name sortKey="Abeliovich, H" uniqKey="Abeliovich H">H Abeliovich</name>
</author>
<author><name sortKey="Acevedo Arozena, A" uniqKey="Acevedo Arozena A">A Acevedo Arozena</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Qu, X" uniqKey="Qu X">X Qu</name>
</author>
<author><name sortKey="Yu, J" uniqKey="Yu J">J Yu</name>
</author>
<author><name sortKey="Bhagat, G" uniqKey="Bhagat G">G Bhagat</name>
</author>
<author><name sortKey="Furuya, N" uniqKey="Furuya N">N Furuya</name>
</author>
<author><name sortKey="Hibshoosh, H" uniqKey="Hibshoosh H">H Hibshoosh</name>
</author>
<author><name sortKey="Troxel, A" uniqKey="Troxel A">A Troxel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yue, Z" uniqKey="Yue Z">Z Yue</name>
</author>
<author><name sortKey="Jin, S" uniqKey="Jin S">S Jin</name>
</author>
<author><name sortKey="Yang, C" uniqKey="Yang C">C Yang</name>
</author>
<author><name sortKey="Levine, Aj" uniqKey="Levine A">AJ Levine</name>
</author>
<author><name sortKey="Heintz, N" uniqKey="Heintz N">N Heintz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Laddha, Sv" uniqKey="Laddha S">SV Laddha</name>
</author>
<author><name sortKey="Ganesan, S" uniqKey="Ganesan S">S Ganesan</name>
</author>
<author><name sortKey="Chan, Cs" uniqKey="Chan C">CS Chan</name>
</author>
<author><name sortKey="White, E" uniqKey="White E">E White</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name>
</author>
<author><name sortKey="Chen, C" uniqKey="Chen C">C Chen</name>
</author>
<author><name sortKey="Xu, Z" uniqKey="Xu Z">Z Xu</name>
</author>
<author><name sortKey="Scuoppo, C" uniqKey="Scuoppo C">C Scuoppo</name>
</author>
<author><name sortKey="Rillahan, Cd" uniqKey="Rillahan C">CD Rillahan</name>
</author>
<author><name sortKey="Gao, J" uniqKey="Gao J">J Gao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tang, H" uniqKey="Tang H">H Tang</name>
</author>
<author><name sortKey="Sebti, S" uniqKey="Sebti S">S Sebti</name>
</author>
<author><name sortKey="Titone, R" uniqKey="Titone R">R Titone</name>
</author>
<author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y Zhou</name>
</author>
<author><name sortKey="Isidoro, C" uniqKey="Isidoro C">C Isidoro</name>
</author>
<author><name sortKey="Ross, Ts" uniqKey="Ross T">TS Ross</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liang, Xh" uniqKey="Liang X">XH Liang</name>
</author>
<author><name sortKey="Jackson, S" uniqKey="Jackson S">S Jackson</name>
</author>
<author><name sortKey="Seaman, M" uniqKey="Seaman M">M Seaman</name>
</author>
<author><name sortKey="Brown, K" uniqKey="Brown K">K Brown</name>
</author>
<author><name sortKey="Kempkes, B" uniqKey="Kempkes B">B Kempkes</name>
</author>
<author><name sortKey="Hibshoosh, H" uniqKey="Hibshoosh H">H Hibshoosh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Delaney, Jr" uniqKey="Delaney J">JR Delaney</name>
</author>
<author><name sortKey="Patel, Cb" uniqKey="Patel C">CB Patel</name>
</author>
<author><name sortKey="Willis, Km" uniqKey="Willis K">KM Willis</name>
</author>
<author><name sortKey="Haghighiabyaneh, M" uniqKey="Haghighiabyaneh M">M Haghighiabyaneh</name>
</author>
<author><name sortKey="Axelrod, J" uniqKey="Axelrod J">J Axelrod</name>
</author>
<author><name sortKey="Tancioni, I" uniqKey="Tancioni I">I Tancioni</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Delaney, Jr" uniqKey="Delaney J">JR Delaney</name>
</author>
<author><name sortKey="Patel, C" uniqKey="Patel C">C Patel</name>
</author>
<author><name sortKey="Mccabe, Ke" uniqKey="Mccabe K">KE McCabe</name>
</author>
<author><name sortKey="Lu, D" uniqKey="Lu D">D Lu</name>
</author>
<author><name sortKey="Davis, Ma" uniqKey="Davis M">MA Davis</name>
</author>
<author><name sortKey="Tancioni, I" uniqKey="Tancioni I">I Tancioni</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Andor, N" uniqKey="Andor N">N Andor</name>
</author>
<author><name sortKey="Graham, Ta" uniqKey="Graham T">TA Graham</name>
</author>
<author><name sortKey="Jansen, M" uniqKey="Jansen M">M Jansen</name>
</author>
<author><name sortKey="Xia, Lc" uniqKey="Xia L">LC Xia</name>
</author>
<author><name sortKey="Aktipis, Ca" uniqKey="Aktipis C">CA Aktipis</name>
</author>
<author><name sortKey="Petritsch, C" uniqKey="Petritsch C">C Petritsch</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Raynaud, F" uniqKey="Raynaud F">F Raynaud</name>
</author>
<author><name sortKey="Mina, M" uniqKey="Mina M">M Mina</name>
</author>
<author><name sortKey="Tavernari, D" uniqKey="Tavernari D">D Tavernari</name>
</author>
<author><name sortKey="Ciriello, G" uniqKey="Ciriello G">G Ciriello</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gao, J" uniqKey="Gao J">J Gao</name>
</author>
<author><name sortKey="Aksoy, Ba" uniqKey="Aksoy B">BA Aksoy</name>
</author>
<author><name sortKey="Dogrusoz, U" uniqKey="Dogrusoz U">U Dogrusoz</name>
</author>
<author><name sortKey="Dresdner, G" uniqKey="Dresdner G">G Dresdner</name>
</author>
<author><name sortKey="Gross, B" uniqKey="Gross B">B Gross</name>
</author>
<author><name sortKey="Sumer, So" uniqKey="Sumer S">SO Sumer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Davoli, T" uniqKey="Davoli T">T Davoli</name>
</author>
<author><name sortKey="Xu, Aw" uniqKey="Xu A">AW Xu</name>
</author>
<author><name sortKey="Mengwasser, Ke" uniqKey="Mengwasser K">KE Mengwasser</name>
</author>
<author><name sortKey="Sack, Lm" uniqKey="Sack L">LM Sack</name>
</author>
<author><name sortKey="Yoon, Jc" uniqKey="Yoon J">JC Yoon</name>
</author>
<author><name sortKey="Park, Pj" uniqKey="Park P">PJ Park</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sack, Lm" uniqKey="Sack L">LM Sack</name>
</author>
<author><name sortKey="Davoli, T" uniqKey="Davoli T">T Davoli</name>
</author>
<author><name sortKey="Li, Mz" uniqKey="Li M">MZ Li</name>
</author>
<author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name>
</author>
<author><name sortKey="Xu, Q" uniqKey="Xu Q">Q Xu</name>
</author>
<author><name sortKey="Naxerova, K" uniqKey="Naxerova K">K Naxerova</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xu, B" uniqKey="Xu B">B Xu</name>
</author>
<author><name sortKey="Lefringhouse, J" uniqKey="Lefringhouse J">J Lefringhouse</name>
</author>
<author><name sortKey="Liu, Z" uniqKey="Liu Z">Z Liu</name>
</author>
<author><name sortKey="West, D" uniqKey="West D">D West</name>
</author>
<author><name sortKey="Baldwin, La" uniqKey="Baldwin L">LA Baldwin</name>
</author>
<author><name sortKey="Ou, C" uniqKey="Ou C">C Ou</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hernandez, L" uniqKey="Hernandez L">L Hernandez</name>
</author>
<author><name sortKey="Kim, Mk" uniqKey="Kim M">MK Kim</name>
</author>
<author><name sortKey="Lyle, Lt" uniqKey="Lyle L">LT Lyle</name>
</author>
<author><name sortKey="Bunch, Kp" uniqKey="Bunch K">KP Bunch</name>
</author>
<author><name sortKey="House, Cd" uniqKey="House C">CD House</name>
</author>
<author><name sortKey="Ning, F" uniqKey="Ning F">F Ning</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Correa, Rj" uniqKey="Correa R">RJ Correa</name>
</author>
<author><name sortKey="Valdes, Yr" uniqKey="Valdes Y">YR Valdes</name>
</author>
<author><name sortKey="Shepherd, Tg" uniqKey="Shepherd T">TG Shepherd</name>
</author>
<author><name sortKey="Dimattia, Ge" uniqKey="Dimattia G">GE DiMattia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dolce, V" uniqKey="Dolce V">V Dolce</name>
</author>
<author><name sortKey="Cappello, Ar" uniqKey="Cappello A">AR Cappello</name>
</author>
<author><name sortKey="Lappano, R" uniqKey="Lappano R">R Lappano</name>
</author>
<author><name sortKey="Maggiolini, M" uniqKey="Maggiolini M">M Maggiolini</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sharifi, Mn" uniqKey="Sharifi M">MN Sharifi</name>
</author>
<author><name sortKey="Mowers, Ee" uniqKey="Mowers E">EE Mowers</name>
</author>
<author><name sortKey="Drake, Le" uniqKey="Drake L">LE Drake</name>
</author>
<author><name sortKey="Collier, C" uniqKey="Collier C">C Collier</name>
</author>
<author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name>
</author>
<author><name sortKey="Zamora, M" uniqKey="Zamora M">M Zamora</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kenific, Cm" uniqKey="Kenific C">CM Kenific</name>
</author>
<author><name sortKey="Wittmann, T" uniqKey="Wittmann T">T Wittmann</name>
</author>
<author><name sortKey="Debnath, J" uniqKey="Debnath J">J Debnath</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hanahan, D" uniqKey="Hanahan D">D Hanahan</name>
</author>
<author><name sortKey="Weinberg, Ra" uniqKey="Weinberg R">RA Weinberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Collins, Ar" uniqKey="Collins A">AR Collins</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Watanabe, Y" uniqKey="Watanabe Y">Y Watanabe</name>
</author>
<author><name sortKey="Honda, S" uniqKey="Honda S">S Honda</name>
</author>
<author><name sortKey="Konishi, A" uniqKey="Konishi A">A Konishi</name>
</author>
<author><name sortKey="Arakawa, S" uniqKey="Arakawa S">S Arakawa</name>
</author>
<author><name sortKey="Murohashi, M" uniqKey="Murohashi M">M Murohashi</name>
</author>
<author><name sortKey="Yamaguchi, H" uniqKey="Yamaguchi H">H Yamaguchi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Foster, Jm" uniqKey="Foster J">JM Foster</name>
</author>
<author><name sortKey="Oumie, A" uniqKey="Oumie A">A Oumie</name>
</author>
<author><name sortKey="Togneri, Fs" uniqKey="Togneri F">FS Togneri</name>
</author>
<author><name sortKey="Vasques, Fr" uniqKey="Vasques F">FR Vasques</name>
</author>
<author><name sortKey="Hau, D" uniqKey="Hau D">D Hau</name>
</author>
<author><name sortKey="Taylor, M" uniqKey="Taylor M">M Taylor</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Olshen, Ab" uniqKey="Olshen A">AB Olshen</name>
</author>
<author><name sortKey="Venkatraman, Es" uniqKey="Venkatraman E">ES Venkatraman</name>
</author>
<author><name sortKey="Lucito, R" uniqKey="Lucito R">R Lucito</name>
</author>
<author><name sortKey="Wigler, M" uniqKey="Wigler M">M Wigler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mathew, R" uniqKey="Mathew R">R Mathew</name>
</author>
<author><name sortKey="Kongara, S" uniqKey="Kongara S">S Kongara</name>
</author>
<author><name sortKey="Beaudoin, B" uniqKey="Beaudoin B">B Beaudoin</name>
</author>
<author><name sortKey="Karp, Cm" uniqKey="Karp C">CM Karp</name>
</author>
<author><name sortKey="Bray, K" uniqKey="Bray K">K Bray</name>
</author>
<author><name sortKey="Degenhardt, K" uniqKey="Degenhardt K">K Degenhardt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fremont, S" uniqKey="Fremont S">S Fremont</name>
</author>
<author><name sortKey="Gerard, A" uniqKey="Gerard A">A Gerard</name>
</author>
<author><name sortKey="Galloux, M" uniqKey="Galloux M">M Galloux</name>
</author>
<author><name sortKey="Janvier, K" uniqKey="Janvier K">K Janvier</name>
</author>
<author><name sortKey="Karess, Re" uniqKey="Karess R">RE Karess</name>
</author>
<author><name sortKey="Berlioz Torrent, C" uniqKey="Berlioz Torrent C">C Berlioz-Torrent</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wei, Pc" uniqKey="Wei P">PC Wei</name>
</author>
<author><name sortKey="Chang, An" uniqKey="Chang A">AN Chang</name>
</author>
<author><name sortKey="Kao, J" uniqKey="Kao J">J Kao</name>
</author>
<author><name sortKey="Du, Z" uniqKey="Du Z">Z Du</name>
</author>
<author><name sortKey="Meyers, Rm" uniqKey="Meyers R">RM Meyers</name>
</author>
<author><name sortKey="Alt, Fw" uniqKey="Alt F">FW Alt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mootha, Vk" uniqKey="Mootha V">VK Mootha</name>
</author>
<author><name sortKey="Lindgren, Cm" uniqKey="Lindgren C">CM Lindgren</name>
</author>
<author><name sortKey="Eriksson, Kf" uniqKey="Eriksson K">KF Eriksson</name>
</author>
<author><name sortKey="Subramanian, A" uniqKey="Subramanian A">A Subramanian</name>
</author>
<author><name sortKey="Sihag, S" uniqKey="Sihag S">S Sihag</name>
</author>
<author><name sortKey="Lehar, J" uniqKey="Lehar J">J Lehar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Marks, Jr" uniqKey="Marks J">JR Marks</name>
</author>
<author><name sortKey="Davidoff, Am" uniqKey="Davidoff A">AM Davidoff</name>
</author>
<author><name sortKey="Kerns, Bj" uniqKey="Kerns B">BJ Kerns</name>
</author>
<author><name sortKey="Humphrey, Pa" uniqKey="Humphrey P">PA Humphrey</name>
</author>
<author><name sortKey="Pence, Jc" uniqKey="Pence J">JC Pence</name>
</author>
<author><name sortKey="Dodge, Rk" uniqKey="Dodge R">RK Dodge</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Schwarz, Rf" uniqKey="Schwarz R">RF Schwarz</name>
</author>
<author><name sortKey="Ng, Ck" uniqKey="Ng C">CK Ng</name>
</author>
<author><name sortKey="Cooke, Sl" uniqKey="Cooke S">SL Cooke</name>
</author>
<author><name sortKey="Newman, S" uniqKey="Newman S">S Newman</name>
</author>
<author><name sortKey="Temple, J" uniqKey="Temple J">J Temple</name>
</author>
<author><name sortKey="Piskorz, Am" uniqKey="Piskorz A">AM Piskorz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ali, Sh" uniqKey="Ali S">SH Ali</name>
</author>
<author><name sortKey="Decaprio, Ja" uniqKey="Decaprio J">JA DeCaprio</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hensley, H" uniqKey="Hensley H">H Hensley</name>
</author>
<author><name sortKey="Quinn, Ba" uniqKey="Quinn B">BA Quinn</name>
</author>
<author><name sortKey="Wolf, Rl" uniqKey="Wolf R">RL Wolf</name>
</author>
<author><name sortKey="Litwin, Sl" uniqKey="Litwin S">SL Litwin</name>
</author>
<author><name sortKey="Mabuchi, S" uniqKey="Mabuchi S">S Mabuchi</name>
</author>
<author><name sortKey="Williams, Sj" uniqKey="Williams S">SJ Williams</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Harter, P" uniqKey="Harter P">P Harter</name>
</author>
<author><name sortKey="Hauke, J" uniqKey="Hauke J">J Hauke</name>
</author>
<author><name sortKey="Heitz, F" uniqKey="Heitz F">F Heitz</name>
</author>
<author><name sortKey="Reuss, A" uniqKey="Reuss A">A Reuss</name>
</author>
<author><name sortKey="Kommoss, S" uniqKey="Kommoss S">S Kommoss</name>
</author>
<author><name sortKey="Marme, F" uniqKey="Marme F">F Marme</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="White, E" uniqKey="White E">E. White</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Silver, Dp" uniqKey="Silver D">DP Silver</name>
</author>
<author><name sortKey="Livingston, Dm" uniqKey="Livingston D">DM Livingston</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lengyel, E" uniqKey="Lengyel E">E. Lengyel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Eckert, Ma" uniqKey="Eckert M">MA Eckert</name>
</author>
<author><name sortKey="Pan, S" uniqKey="Pan S">S Pan</name>
</author>
<author><name sortKey="Hernandez, Km" uniqKey="Hernandez K">KM Hernandez</name>
</author>
<author><name sortKey="Loth, Rm" uniqKey="Loth R">RM Loth</name>
</author>
<author><name sortKey="Andrade, J" uniqKey="Andrade J">J Andrade</name>
</author>
<author><name sortKey="Volchenboum, Sl" uniqKey="Volchenboum S">SL Volchenboum</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Oren, M" uniqKey="Oren M">M Oren</name>
</author>
<author><name sortKey="Rotter, V" uniqKey="Rotter V">V Rotter</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cole, Aj" uniqKey="Cole A">AJ Cole</name>
</author>
<author><name sortKey="Dwight, T" uniqKey="Dwight T">T Dwight</name>
</author>
<author><name sortKey="Gill, Aj" uniqKey="Gill A">AJ Gill</name>
</author>
<author><name sortKey="Dickson, Ka" uniqKey="Dickson K">KA Dickson</name>
</author>
<author><name sortKey="Zhu, Y" uniqKey="Zhu Y">Y Zhu</name>
</author>
<author><name sortKey="Clarkson, A" uniqKey="Clarkson A">A Clarkson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cicchini, M" uniqKey="Cicchini M">M Cicchini</name>
</author>
<author><name sortKey="Chakrabarti, R" uniqKey="Chakrabarti R">R Chakrabarti</name>
</author>
<author><name sortKey="Kongara, S" uniqKey="Kongara S">S Kongara</name>
</author>
<author><name sortKey="Price, S" uniqKey="Price S">S Price</name>
</author>
<author><name sortKey="Nahar, R" uniqKey="Nahar R">R Nahar</name>
</author>
<author><name sortKey="Lozy, F" uniqKey="Lozy F">F Lozy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Yk" uniqKey="Wang Y">YK Wang</name>
</author>
<author><name sortKey="Bashashati, A" uniqKey="Bashashati A">A Bashashati</name>
</author>
<author><name sortKey="Anglesio, Ms" uniqKey="Anglesio M">MS Anglesio</name>
</author>
<author><name sortKey="Cochrane, Dr" uniqKey="Cochrane D">DR Cochrane</name>
</author>
<author><name sortKey="Grewal, Ds" uniqKey="Grewal D">DS Grewal</name>
</author>
<author><name sortKey="Ha, G" uniqKey="Ha G">G Ha</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lemasters, Jj" uniqKey="Lemasters J">JJ Lemasters</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jena, Nr" uniqKey="Jena N">NR Jena</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Behrends, C" uniqKey="Behrends C">C Behrends</name>
</author>
<author><name sortKey="Sowa, Me" uniqKey="Sowa M">ME Sowa</name>
</author>
<author><name sortKey="Gygi, Sp" uniqKey="Gygi S">SP Gygi</name>
</author>
<author><name sortKey="Harper, Jw" uniqKey="Harper J">JW Harper</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Koukourakis, Mi" uniqKey="Koukourakis M">MI Koukourakis</name>
</author>
<author><name sortKey="Kalamida, D" uniqKey="Kalamida D">D Kalamida</name>
</author>
<author><name sortKey="Giatromanolaki, A" uniqKey="Giatromanolaki A">A Giatromanolaki</name>
</author>
<author><name sortKey="Zois, Ce" uniqKey="Zois C">CE Zois</name>
</author>
<author><name sortKey="Sivridis, E" uniqKey="Sivridis E">E Sivridis</name>
</author>
<author><name sortKey="Pouliliou, S" uniqKey="Pouliliou S">S Pouliliou</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schaaf, Mb" uniqKey="Schaaf M">MB Schaaf</name>
</author>
<author><name sortKey="Keulers, Tg" uniqKey="Keulers T">TG Keulers</name>
</author>
<author><name sortKey="Vooijs, Ma" uniqKey="Vooijs M">MA Vooijs</name>
</author>
<author><name sortKey="Rouschop, Km" uniqKey="Rouschop K">KM Rouschop</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, J" uniqKey="Zhang J">J. Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lai, Dh" uniqKey="Lai D">DH Lai</name>
</author>
<author><name sortKey="Gavin" uniqKey="Gavin">Gavin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fungtammasan, A" uniqKey="Fungtammasan A">A Fungtammasan</name>
</author>
<author><name sortKey="Walsh, E" uniqKey="Walsh E">E Walsh</name>
</author>
<author><name sortKey="Chiaromonte, F" uniqKey="Chiaromonte F">F Chiaromonte</name>
</author>
<author><name sortKey="Eckert, Ka" uniqKey="Eckert K">KA Eckert</name>
</author>
<author><name sortKey="Makova, Kd" uniqKey="Makova K">KD Makova</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gyorffy, B" uniqKey="Gyorffy B">B Gyorffy</name>
</author>
<author><name sortKey="Lanczky, A" uniqKey="Lanczky A">A Lanczky</name>
</author>
<author><name sortKey="Eklund, Ac" uniqKey="Eklund A">AC Eklund</name>
</author>
<author><name sortKey="Denkert, C" uniqKey="Denkert C">C Denkert</name>
</author>
<author><name sortKey="Budczies, J" uniqKey="Budczies J">J Budczies</name>
</author>
<author><name sortKey="Li, Q" uniqKey="Li Q">Q Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schindelin, J" uniqKey="Schindelin J">J Schindelin</name>
</author>
<author><name sortKey="Arganda Carreras, I" uniqKey="Arganda Carreras I">I Arganda-Carreras</name>
</author>
<author><name sortKey="Frise, E" uniqKey="Frise E">E Frise</name>
</author>
<author><name sortKey="Kaynig, V" uniqKey="Kaynig V">V Kaynig</name>
</author>
<author><name sortKey="Longair, M" uniqKey="Longair M">M Longair</name>
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<region><li>Californie</li>
<li>Caroline du Nord</li>
<li>Caroline du Sud</li>
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<settlement><li>Columbia (Caroline du Sud)</li>
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<orgName><li>Université de Caroline du Sud</li>
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<tree><country name="États-Unis"><region name="Californie"><name sortKey="Delaney, Joe R" sort="Delaney, Joe R" uniqKey="Delaney J" first="Joe R." last="Delaney">Joe R. Delaney</name>
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<name sortKey="Delaney, Joe R" sort="Delaney, Joe R" uniqKey="Delaney J" first="Joe R." last="Delaney">Joe R. Delaney</name>
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<name sortKey="Haghighiabyaneh, Mina" sort="Haghighiabyaneh, Mina" uniqKey="Haghighiabyaneh M" first="Mina" last="Haghighiabyaneh">Mina Haghighiabyaneh</name>
<name sortKey="Haghighiabyaneh, Mina" sort="Haghighiabyaneh, Mina" uniqKey="Haghighiabyaneh M" first="Mina" last="Haghighiabyaneh">Mina Haghighiabyaneh</name>
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<name sortKey="La Spada, Albert R" sort="La Spada, Albert R" uniqKey="La Spada A" first="Albert R." last="La Spada">Albert R. La Spada</name>
<name sortKey="La Spada, Albert R" sort="La Spada, Albert R" uniqKey="La Spada A" first="Albert R." last="La Spada">Albert R. La Spada</name>
<name sortKey="Ortell, Katherine K" sort="Ortell, Katherine K" uniqKey="Ortell K" first="Katherine K." last="Ortell">Katherine K. Ortell</name>
<name sortKey="Patel, Chandni B" sort="Patel, Chandni B" uniqKey="Patel C" first="Chandni B." last="Patel">Chandni B. Patel</name>
<name sortKey="Patel, Chandni B" sort="Patel, Chandni B" uniqKey="Patel C" first="Chandni B." last="Patel">Chandni B. Patel</name>
<name sortKey="Ramos Zapatero, Maria" sort="Ramos Zapatero, Maria" uniqKey="Ramos Zapatero M" first="Maria" last="Ramos-Zapatero">Maria Ramos-Zapatero</name>
<name sortKey="Ramos Zapatero, Maria" sort="Ramos Zapatero, Maria" uniqKey="Ramos Zapatero M" first="Maria" last="Ramos-Zapatero">Maria Ramos-Zapatero</name>
<name sortKey="Ramos Zapatero, Maria" sort="Ramos Zapatero, Maria" uniqKey="Ramos Zapatero M" first="Maria" last="Ramos-Zapatero">Maria Ramos-Zapatero</name>
<name sortKey="Schlaepfer, David D" sort="Schlaepfer, David D" uniqKey="Schlaepfer D" first="David D." last="Schlaepfer">David D. Schlaepfer</name>
<name sortKey="Schlaepfer, David D" sort="Schlaepfer, David D" uniqKey="Schlaepfer D" first="David D." last="Schlaepfer">David D. Schlaepfer</name>
<name sortKey="Stupack, Dwayne G" sort="Stupack, Dwayne G" uniqKey="Stupack D" first="Dwayne G." last="Stupack">Dwayne G. Stupack</name>
<name sortKey="Stupack, Dwayne G" sort="Stupack, Dwayne G" uniqKey="Stupack D" first="Dwayne G." last="Stupack">Dwayne G. Stupack</name>
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   |texte=   Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors
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Serveur d'exploration Chloroquine

Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors

Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors

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